Studies on Hypersensitiveness to Diphtheria Bacilli
نویسندگان
چکیده
The paper describes an "immediate" skin reaction to derivatives of the diphtheria bacillus which is shown to be distinct from the "delayed" or "pseudoreaction" commonly seen in Schick tests on adults. The "immediate" reaction was passively transferred to local areas of the skin of other people.
منابع مشابه
STUDIES ON HYPERSENSITIVENESS TO DIPHTHERIA BACILLI. I. AN "I~m~mAT~." SxrN REACTION WHICH CAN BE PASSIVELY TRANSFERRED
Hypersensitiveness of man to bacteria is of general importance because of its unknown effects upon infection and resistance and upon the manifestation of disease. From at least one aspect, hypersensitiveness to diphtheria bacilli seems to be especially important. While there are few diseases in which the manifestations can be referred so directly to the toxin, there are few pathogenic bacteria ...
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Antibiotics are of equal importance to antitoxin in the treatment of diphtheria, as an effective antibiotic rapidly halts the production of toxin. There appear to have been only two reports of the sensitivity of diphtheria bacilli to various antibiotics and these are based on the examination of less than 60 strains. In this paper the sensitivity of 192 strains to eight representative antibiotic...
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1. When a guinea pig with well developed peritoneal tuberculosis is injected intraperitoneally with about 20 cc. of a heavy suspension of a virulent tubercle bacillus (Culture H37) death occurs within 24 hours or the animal becomes extremely toxic. Such a peritoneal tuberculosis develops in about 1 month after 1 cc. of. a very heavy suspension of Culture H37 has been introduced into the abdomin...
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Serum therapy in the form in which it finds application in the treatment of diphtheria patients is an antitoxic or detoxicating curative method. It is based on the view, held by Löffler in Germany and by Roux in France, that the parasites causing diphtheria, the Löffler diphtheria bacilli, do not themselves cause diphtheria, but that they produce poisons which cause the disease to develop. With...
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Prior observations on the cellular reactions to tuberculo-phosphatide are confirmed and compared with reactions induced by this material in tuberculous animals. In the latter the response is accelerated and augmented and simulates the Koch phenomenon. Tuberculo-protein produces no macroscopic reaction in normal animals. The microscopic reaction of neutrophiles and monocytes regresses in less th...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 49 شماره
صفحات -
تاریخ انتشار 2003